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Essentials: The Science of Gratitude & How to Build a Gratitude Practice
Oct 23, 2025 · 40 min
In this Huberman Lab Essentials episode, I explore the science of gratitude and how to develop an effective, research-supported gratitude practice.
I explain why common gratitude practices (like simply listing things you're grateful for) are far less impactful than engaging in story-based gratitude practices. I also explain how being grateful activates specific brain regions, which enhance calm, social connection and motivation, while reducing anxiety and inflammation. Finally, I share why we can't simply trick our brains into feeling grateful and describe a practical weekly gratitude practice that will improve both your mental and physical well-being.
Read the episode show notes at hubermanlab.com.
Thank you to our sponsors
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Timestamps
(0:00) Gratitude
(0:30) Gratitude Practice Benefits
(3:22) Pro-Social vs Defensive Behaviors, Gratitude
(6:25) Sponsor: Eight Sleep
(8:07) Serotonin, Brain & Context, Gratitude Mindset
(14:02) Context, Can You Lie to Yourself?
(14:48) Effective Gratitude Practice, Tools: Receiving Gratitude, Story
(21:18) Sponsor: AGZ by AG1
(22:47) Tool: Find & Revisit Inspirational Stories
(27:30) Heartfelt Intention, Genuine Thanks
(29:42) Sponsor: Our Place
(31:03) Gratitude Practice Benefits for Anxiety, Fear & Motivation
(33:29) Gratitude Practice Benefits for Immune System
(36:02) Recap: Establishing an Effective Gratitude Practice
Disclaimer & Disclosures
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